American Airlines has committed to a $200 million equity investment in China Southern Airlines, clearing the flight path for a long-term relationship between two of the world’s biggest carriers and adding over 100 destinations in Asia and the Americas.

Fort Worth-based American (Nasdaq: AAL) is the world’s largest airline, and Guangzhou-based China Southern is the largest airline in the critically important market of China.

“China Southern’s extensive network within China touches developing…